The College is located at College Drive Port Macquarie on the Mid North Coast of New South Wales. It is located approximately 420 kilometres from Sydney and 520 kilometres from Brisbane.

The school is situated 10 kilometres from the Port Macquarie Town Centre and 10 kilometres from Wauchope which allows a better location for students who live at Wauchope, Telegraph Point and Laurieton.

Zoning for St Joseph’s Regional College is West of Kooloonbung Creek and South of Houston Mitchell Drive

Zoning for MacKillop College is East of Kooloonbung Creek (except for small St Joseph’s Primary School area) North of Houston Mitchell Drive